MetProc - Separate Metabolites into Likely Measurement Artifacts and True
Metabolites
Split an untargeted metabolomics data set into a set of
likely true metabolites and a set of likely measurement
artifacts. This process involves comparing missing rates of
pooled plasma samples and biological samples. The functions
assume a fixed injection order of samples where biological
samples are randomized and processed between intermittent
pooled plasma samples. By comparing patterns of missing data
across injection order, metabolites that appear in blocks and
are likely artifacts can be separated from metabolites that
seem to have random dispersion of missing data. The two main
metrics used are: 1. the number of consecutive blocks of
samples with present data and 2. the correlation of missing
rates between biological samples and flanking pooled plasma
samples.